Journal of Medical Case Reports and Reviews

Received 20 June 2025 | Accepted 25 June 2025 | Published Online 5 July 2025

DOI:https://doi.org/10.52845/JMCRR/2025/8-7-4 JMCRR 08 (7), 1515-1521
ISSN (O) 2589-8655 | (P) 2589-8647 IF: 2.964

Correlation Between Procalcitonin and Creatinine Levels in Sepsis Patients

Muhammad Faisal Kusumaputra1, Ronald Irwanto Natadidjaja2, 3*

1.Undergraduate Medical StudyProgram, Faculty of Medicine,Universitas Trisakti
2.Department of InternalMedicine, Faculty of Medicine,Universitas Trisakti
3.Trisakti-RASPRO IndonesiaAntimicrobial Stewardship (TRIASE) Learning Centre

Abstract:
BACKGROUND: Procalcitonin is a very important biochemical marker that is closely correlated with the severity of the host’s inflammatory response to microbial infection. Creatinine is a breakdown product of creatine that provides energy for muscles, which is then released into the blood, after which it passes through the kidneys and is excreted. These two parameters are related in several circumstances, especially in patients with severe bacterial infections that can affect kidney function. The purpose of this study was to determine the correlation between procalcitonin and creatinine levels in sepsis patients.
METHODS: This study used an observational analytical design with a cross-sectional approach. The population of this study was sepsis patients who were in the emergency unit of the Karawang Regional General Hospital. The sample selection technique used was consecutive sampling. Data were obtained through patient medical records. Data were processed and analyzed using the Spearman Correlation Test.
RESULTS: Based on the results of the study on 30 respondents, there was a significant correlation between procalcitonin levels and creatinine in sepsis patients at the Karawang General Hospital (r = 0.755; p = <0.001).
CONCLUSION: There was a significant correlation between procalcitonin levels and creatinine in sepsis patients at the Karawang General Hospital.

Keywords: Procalcitonin, Creatinine, Sepsis